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. 2023 Jan 13;13:1062067. doi: 10.3389/fimmu.2022.1062067

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Copyright © 2023 Maaske, Sproule, Falsey, Sobieszczyk, Luetkemeyer, Paulsen, Riddler, Robb, Rolle, Sha, Tong, Ahani, Aksyuk, Bansal, Egan, Jepson, Padilla, Patel, Shoemaker, Stanley, Swanson, Wilkins, Villafana, Green and Kelly

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Illness visit day 1 SARS-CoV-2 nAb titers display low-moderate negative correlations with SARS-CoV-2 virologic outcomes. Scatterplot analysis depicting the relationship between (A) SARS-CoV-2 viral load in nasopharyngeal swabs (B) SARS-CoV-2 viral load in saliva samples, and (C) duration of viral shedding in saliva (y-axes) and illness visit day 1 nAb titers (x-axes) in vaccinees and placebo recipients. Blue and red shading denotes 95% CI. Dotted line denotes 95% prediction limits. Clustering of participants along the y-axis occurs due to levels of serum anti-SARS-CoV-2 neutralizing antibody falling below the assay lower limit of quantification (LLOQ). LLOQ= 40 ID50. 50% of LLOQ =20 ID50.