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[Preprint]. 2023 Jan 4:2023.01.03.521203. [Version 1] doi: 10.1101/2023.01.03.521203

Figure 4. A diet and PA interventions reduce body weight but do not delay tumor growth in an obese orthotopic mouse model of PDAC.

Figure 4.

(A) 42-day old male C57BL/6J mice (n=10 per group) were placed on a DIO intervention with HFD for nine weeks before starting a 59-day CD and/or PA intervention. Mice were implanted with tumors and resumed their diet intervention. (B) Distance ran in kilometers analyzed via two-way ANOVA after log transformation. (C) BW change over time, analyzed with mixed-effects analysis comparing to HFD control. (D) Average change in BW from day 56 to the end of the intervention analyzed with two-way ANOVA. (E) Average tumor weight, analyzed via two-way ANOVA after log-transformation. (F) Average photon radiance signal from the tumor/week, analyzed after log-transformation via two-way ANOVA.