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[Preprint]. 2023 Jan 2:2023.01.01.522436. [Version 1] doi: 10.1101/2023.01.01.522436

Fig.1. The RIPTAC hypothesis and the HaloTag-FKBP model system.

Fig.1

a) RIPTACs leverage target-dependent intracellular accumulation and positive co-operativity in ternary complex formation to selectively inhibit the proliferation of target protein expressing cells. b) The HaloTag-FKBP fusion protein is selectively expressed in 293_HFL cells and not in the control 293_GFPL cells. c) Quantitation of cellular HaloTag-FKBP concentration using recombinant HaloTag-GST standard curve. d) RIPTAC Effector Ligands (ELs) JQ-1, BI2536, TMX-3013, Dinaciclib, and the FKBP Target Ligand (TL) HLDA-001.