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a) The FKBP ligand accumulates selectively in 293_HFL cells b) Non-covalent RIPTACs also accumulate selectively in 293_HFL cells c&d) RIPTAC activity in 7 day viability assays can be competed off by pre-treatment with 10μM HLDA-001 in the case of non-covalent RIPTACs and 300nM TAMRA-CA in the case of covalent RIPTACs e) RIPTAC HLDA-119 is a 20-fold more potent CDK9 inhibitor in 293_HFL cells than in control 293_GFPL cells.
