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[Preprint]. 2023 Jan 9:2023.01.09.522931. [Version 1] doi: 10.1101/2023.01.09.522931

Figure 5. PF4 attenuates cfDNA-induced coagulability in vivo.

Figure 5.

(A) Top: schematic of study in which WT mice or cxcl4−/− littermates were given normal saline vehicle or normal saline containing digested DNA prior to blood collection at 30 minutes or 4 hours. Bar graph: TAT levels using a commercial ELISA kit in platelet-poor plasma. Data are mean ± SEM of at least 3 independent experiments as indicated in each bar. (B) Top: schematic of study in which WT mice received normal saline vehicle or LPS, and a subset of animals was given hPF4 by tail-vein injection immediately following LPS injection. TAT levels were measured in blood was drawn at baseline and 6-hours post LPS ± PF4 infusion. Bar graphs: TAT levels (left) and cfDNA levels (right) at 6-hours post LPS challenge. Data are mean ± SEM of at least 5 independent experiments as indicated in each bar.