FIG. 5.

Acidosis of blood in CD8⁺ T-cell-depleted mice infected with P. berghei malaria. Serum lactate (A), HCO₃⁻ (C), and glutamate (D) levels were measured in groups of four mice at zero time and on day 6 of P. berghei malaria. The groups of infected mice were treated with either anti-CD8 mAb or control rat IgG. The blood pH (B) was measured with a separate set of experimental animals. Two of five mice in the control rat IgG-injected group died on day 6 of infection before blood was obtained for pH measurement, so the pH values are averages based on the data for three mice. Similar results were obtained in a duplicate experiment. An asterisk indicates statistical significance (P < 0.05) for a comparison of a group of infected mice and uninfected controls.