Table 2:

Prioritized list of coding sequence variants between the Py17X and Py17XNL genome.

Py17X Gene ID	Py17XNL Gene ID	Gene Name	Chromosome Position	Py17X DNA	Py17XNL DNA	Mutation Type	AA Change	Protein Alignment
PY17X_0811400	Py17XNL_0801678	proteasome subunit alpha type‐3.1	529296	G	A	Missense Variant	Val24Ile	Py17X MAGLSAGYDLSVSTFSPDGRLYQVEYIYKAINNNNTSISLECKDGVISCSINTSLEKNKMIKKNSYNRIYYV 17XNL MAGLSAGYDLSVSTFSPDGRLYQIEYIYKAINNNNTSISLECKDGVISCSINTSLEKNKMIKKNSYNRIYYV Cons ***********************:************************************************
PY17X_0316900	Py17XNL_0303734	Plasmodium exported protein	625346	G	A	Missense Variant	Gly1324Ser	Py17X PEQKENGDIGEASNNAAELKENMNDLLKDTIEISKESIKEHDAQSIMFTRKFIKHVSGYDIQKAKDHPTDED 17XNL PEQKENGDIGEASNNAAELKENMNDLLKDTIEISKESIKEHDAQSIMFTRKFIKHVSSYDIQKAKDHPTDED Cons *********************************************************.**************
PY17X_1022000	Py17XNL_1002268	PP7	964836	C	A	Missense Variant	Leu342Phe	Py17X FAFKLSNYDSVIINRGNHECSYMNEVYGFHNEVLSKYDESVFDIFQEIFELLSLSVNIQNQIFVVHGGLSRY 17XNL FAFKLSNYDSVIINRGNHECSYMNEVYGFHNEVLSKYDESVFDIFQEIFELLSFSVNIQNQIFVVHGGLSRY Cons *****************************************************:******************
PY17X_1419800	Py17XNL_1401046	ACDC domain-containing protein	839701	G	T	Missense Variant	Arg1562Ile	Py17X VNENFTAELNGVQMYNGNEKKKKKKNYSLSINKNNGNIKDNENTNEILLRYENEVYAPNNDVEKNLIEDNNI 17XNL VNENFTAELNGVQMYNGNEKKKKKKNYSLSINKNNGNIKDNENTNEILLIYENEVYAPNNDVEKNLIEDNNI Cons *************************************************:**********************
PY17X_0106400	Py17XNL_0104725	RNA-binding protein	339741	AGATAGG	A	Disruptive Inframe Deletion	Asp578_Arg579del	Py17X RDRDRDRDRDRDRDRDRDRDRDRR 17XNL RDRDR--DRDRDRDRDRDRDRDRR Cons ***** *****************
PY17X_1206500	Py17XNL_1204935	UTP25	344114	GGAAAATGGGAAT	G	Disruptive Inframe Deletion	Gly163_Asn166del	Py17X ENGNENGNENGNENGNENGNENDKNGNDKNGNDKNGNDKNEASSFQSKDEIYMNILINNIKSQNEDFLNVKE 17XNL ENGNENGNENGNENGNEN-----DKNGNDKNGNDKNGNDKNEASSFQSKDEIYMNILINNIKSQNEDFLNVKE Cons ****************** **************************************************
PY17X_1110800	Py17XNL_1105517	KH domain-containing protein	539935	G	GTTA	Disruptive Inframe Insertion	Asn1809dup	Py17X NNNVGRDNIIRKENKGIMMHDDKDKFSKGGNNRYFGDKTNNFNNKN-NNNNNNNNNNNNNNNNNNAKNNYLSKDSMI 17XNL NNNVGRDNIIRKENKGIMMHDDKDKFSKGGNNRYFGDKTNNFNNKNNNNNNNNNNNNNNNNNNNNAKNNYLSKDSMI Cons ********************************************** ******************************
PY17X_1334500	Py17XNL_1303202	AP2-SP	1594433	AAC, T, AC	GCT, C, TA	Synonymous and Missense Variant	Val133Tyr, Val136Ser	Py17X QINYNISNDIMNTVPSTNCDVTHDSVSSVPNNAFENVENVKNVENVENVKNVENVENVENVENVENVENYEN 17XNL QINYNISNDIMNTVPSTNCDVTHDSVSSVPNNAFENVENVKNVENVENVKNVENVENVENYENSENVENYEN Cons ************************************************************ ** ********
PY17X_1128400	Py17XNL_1105678	PK4	1187719	T	TGAA	Conservative Inframe Insertion	Glu266dup	Py17X FYNSYNYCNNNNSKRDEKIEKNIVEKNIENKYNIKEYDKTNKSILFPIE-EFKKIIQIENNIERNYIVPKES 17XNL FYNSYNYCNNNNSKRDEKIEKNIVEKNIENKYNIKEYDKTNKSILFPIEEEFKKIIQIENNIERNYIVPKES Cons ************************************************* **********************
PY17X_1451200	Py17XNL_1401341	BDP5	2018932	A	AAATATAAAC	Disruptive Inframe Insertion	Asn320_Asn321insAsnIleAsn	Py17X NKIRSKNEINNSPNTDKVEKNIN---NINNINNINNNTNNNNVHEYVPNNLNDEFIEEKKLDKNKFNEYKNN 17XNL NKIRSKNEINNSPNTDKVEKNINNINNINNINNINNNTNNNNVHEYVPNNLNDEFIEEKKLDKNKFNEYKNN Cons *********************** **********************************************
PY17X_0942100	Py17XNL_0900429	PAIP1	1662686	A	AAAT	Disruptive Inframe Insertion	Asn1941dup	Py17X NVNKNKEIGKDEIQINSQINNLDDNAKGKKSNIFNQAKSSYKYPAEEGENNSNTNTSTEN-NNNNNNNNNNKT 17XNL NVNKNKEIGKDEIQINSQINNLDDNAKGKKSNIFNQAKSSYKYPAEEGENNSNTNTSTENNNNNNNNNNNNKT Cons ************************************************************ ************
PY17X_0106100	Py17XNL_0104722	RAD50	324089	CGTT	C	Disruptive Inframe Deletion	Gln834del	Py17X ENITNCVNKNEDILSDNLIKLESKKRVTAHFEELENGMKKKQRQEQDKFETVQKMKIEKIEKISKIEKINKI 17XNL ENITNCVNKNEDILSDNLIKLESKKRVTAHFEELENGMKKK-RQEQDKFETVQKMKIEKIEKISKIEKINKI Cons ***************************************** ******************************
PY17X_1001900	Py17XNL_1204888	erythrocyte membrane antigen 1	174565	TAAATGA	T	Conservative Inframe Deletion	Asn287_Glu288del	Py17X SYLNNGENAEDQELDDEVASCFADGENVNDKELDEVISYLANGENVNVNVNENVNENVNENVNENENENENE 17XNL SYLNNGENAEDQELDDEVASCFADGENVNDKELDEVISYLANGENVNVNVNENVNENVNENVNE--NENENE Cons **************************************************************** ******