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[Preprint]. 2023 Jan 10:2023.01.09.523303. [Version 1] doi: 10.1101/2023.01.09.523303

Fig. 1: Schematic illustrating extraction and amplification of LBD Asyn fibrils derived from postmortem tissue samples.

Fig. 1:

a, Fibrils were isolated in an insoluble fraction by sequential extraction and centrifugation of tissue samples. The insoluble fraction seeds were combined with recombinant Asyn monomer and subjected to multiple rounds of sonication followed by quiescent incubation at 37 °C to generate amplified fibrils. b-d, Representative negative stain TEM images of LBD amplified fibrils.