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[Preprint]. 2023 Jan 18:2023.01.15.524135. [Version 1] doi: 10.1101/2023.01.15.524135

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Figure 3: — Comparison of expert and AnnoSpat endocrine cell-type annotation. (A, B) Proportion of expert-annotated (A) and AnnoSpat-annotated (B) endocrine cell types from the IMC of different pancreas regions of donors studied in¹⁶. (C, D) Representative protein channel intensities (expression levels) from IMC images of donors with discordant expert and AnnoSpat cell-type annotation is overlaid with AnnoSpat predicted cell types (C) or endocrine canonical marker protein channels (D). (E) From left to right, top to bottom: TooManyCells tree overlaid by AnnoSpat-predicted cell types, and expression levels of c-peptide, glucagon, somatostatin, pancreatic polypeptide protein (PPY), and ghrelin marking beta, alpha, delta, PP, and epsilon cells, respectively in n = 65, 643 cells across m = 141 slides of 16 pancreas donors. (F, G) Six representative IMC images from m = 141 slides of 16 donors overlaid by AnnoSpat-predicted cell types (F) or endocrine canonical marker protein channels (G).