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[Preprint]. 2023 Jan 12:2023.01.12.523639. [Version 1] doi: 10.1101/2023.01.12.523639

Figure 3. Depletion of WASp, N-WASp or DIAPH1 leads to increase in replication fork collapse.

Figure 3

A. Representative images and dot plots of the number of 53BP1 foci per cyclin A positive HeLa cells treated with control siRNA (siCTRL) or siRNA targeting N-WASp, DIAPH1 or WASp upon HU treatment. Dot plots represent data pooled from three independent experiments. Statistical significance was determined using the Mann-Whitney test. Representative images and quantification of micronuclei formation in HeLa cells treated with control siRNA (−) or siRNA targeting N-WASp, DIAPH1 or WASp (+). Dot plots represent data pooled from at least three independent experiments. Bar charts represent mean +/− SEM of three experiments and statistical significance was determined using t test.