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[Preprint]. 2023 Jan 20:2023.01.20.524596. [Version 1] doi: 10.1101/2023.01.20.524596

Figure 1. D2R upregulation in NAc CINs increases delay discounting.

Figure 1.

A. Schematic illustration of delay discounting task. On free choice trials, two lever options are presented, each leading to a small or a large reward. The delay to the large reward is progressively increased across sessions (0 – 10 s), while the small reward is given with no delay. B. In the absence of delays to either reward, EGFP and D2R-overexpressing mice similarly increased preference for the large reward option after 14 training sessions (shown here as blocks of 2 sessions). C. With increasing delays to the large reward, both groups showed discounting, an effect that was significantly greater following CIN D2R upregulation. *p < 0.0001 denotes significant virus × delay interaction, n = 8 mice/group. D. In the same mice, latency to make a choice following lever extension in free choice trials was not altered by D2R upregulation. E, F. No significant changes were observed in distance traveled in a 90-min open field session (EGFP n = 9; D2 n = 11).