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[Preprint]. 2023 Jan 20:2023.01.20.524596. [Version 1] doi: 10.1101/2023.01.20.524596

Figure 4. CIN D2R upregulation in NAc does not alter timing.

Figure 4.

A. Schematic representation of the temporal discrimination task. In each session, a single response on one of two lever options is rewarded based on the duration of the sample auditory conditioned stimulus (CS). Two tone durations are presented in each session. B. Mean proportion of correct responses on the corresponding lever in 2-s tone trials (short, left) or 8-s tone trials (long, right) across blocks of 2 sessions. C. The duration of tones was proportionally increased to 6 s (short, left) and 24 s (long, right). CIN D2R upregulation did not alter discrimination of tone durations in either combination. D Mean lever press rate during peak trials in the final five sessions of the 24-s peak interval task. E-G. Mean best-fitting parameters (derived from fitting to Gaussian function) for peak location (timing accuracy), peak width (timing precision), or peak height (peak response rate). No significant differences were observed in any of these parameters (EGFP, n = 8; D2, n = 7).