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[Preprint]. 2023 Jan 19:2023.01.18.23284664. [Version 1] doi: 10.1101/2023.01.18.23284664

Figure 1. Overview of the study.

Figure 1.

Rare germline PVs, cryptic splice variants and copy number variants were characterized in 1,436 RCC patients. Gene-level burden analysis was restricted to 1,356 RCC patients ancestry-matched with 16,512 cancer-free controls after genetic ancestry inference and case-control pair-matching (Method). CHEK2 focused analysis was restricted to 1,201 European RCC patients and 20,264 European cancer-free controls.