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[Preprint]. 2023 Jan 19:2023.01.18.23284664. [Version 1] doi: 10.1101/2023.01.18.23284664

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Figure 4. — A) Comutation plot summarizing germline and somatic variants in RCC patients with germline pathogenic variants in the three significantly enriched genes as well as CHEK2. For the somatic events, only variants in relevant genes are featured. The dotted horizontal line on the bar plot indicates the age of onset at 45. CNA indicates copy number alterations

B) Density plot (left) and Box plot (right) for the distribution of age of disease onset for the different pathogenic variant carrier groups. Adjusted p-value was calculated after a one-way ANOVA with post hoc Tukey’s HDS test.