Table 2.
Univariate Cox regression for 60-day mortality for CSF metabolites
| Metabolites | HR1 | 95% CI1 | p-value | FDR2 |
|---|---|---|---|---|
| tryptophan | 1.16 | 1.10, 1.24 | <0.001 | <0.001 |
| kynurenine | 1.00 | 0.93, 1.07 | >0.9 | >0.9 |
| kynurenic acid | 1.00 | 0.93, 1.07 | 0.9 | >0.9 |
| 3-hydroxyanthranilic acid | 1.01 | 0.97, 1.05 | 0.6 | 0.9 |
| xanthurenic acid | 0.95 | 0.90, 1.00 | 0.05 | 0.2 |
| quinolinic acid | 0.92 | 0.85, 1.00 | 0.038 | 0.2 |
| niacinamide | 1.03 | 0.95, 1.11 | 0.5 | 0.8 |
| 3-indoleacetic acid | 1.11 | 0.96, 1.29 | 0.2 | 0.4 |
| N-acetylserotonin | 1.01 | 0.94, 1.09 | 0.7 | 0.9 |
| 5-methoxytryptophol | 1.11 | 0.93, 1.32 | 0.3 | 0.5 |
Legend: Cox regression models were stratified by cohort and adjusted by sex, age, and HIV status. Hazard ratio (HR) was calculated per 2-fold increase in metabolite concentration.
1
HR = Hazard ratio, CI = Confidence interval.
2
FDR=False Discovery Rate; Benjamini & Hochberg correction for multiple testing.