Table 2.
Associationsa of the plasma omega-6/omega-3 PUFAs ratio with all-cause, cancer, and CVD mortality risk in the UK Biobank.
| Causes of death |
|||||||||
|---|---|---|---|---|---|---|---|---|---|
| Omega ratio variable forms | All-cause |
Cancer |
Cardiovascular diseases |
||||||
| Number of deaths | Partially adjusted associationsb | Fully adjusted associationsc | Number of deaths | Partially adjusted associationsb | Fully adjusted associationsc | Number of deaths | Partially adjusted associationsb | Fully adjusted associationsc | |
| HR (95% CI) | HR (95% CI) | HR (95% CI) | HR (95% CI) | HR (95% CI) | HR (95% CI) | ||||
|
| |||||||||
| Continuous | 6,461 | 1.02 (1.02–1.03) | 1.02 (1.02–1.03) | 2,794 | 1.02 (1.01–1.03) | 1.01 (1.00–1.02) | 1,668 | 1.02 (1.01–1.03) | 1.02 (1.01–1.03) |
|
| |||||||||
| Quintiles (median) | |||||||||
|
| |||||||||
| 1 (5.9) | 1,348 | 1.00 (ref) | 1.00 (ref) | 593 | 1.00 (ref) | 1.00 (ref) | 369 | 1.00 (ref) | 1.00 (ref) |
| 2 (7.6) | 1,256 | 1.00 (0.92–1.08) | 0.96 (0.88–1.05) | 563 | 1.02 (0.91–1.15) | 0.98 (0.86–1.12) | 315 | 0.90 (0.77–1.05) | 0.89 (0.75–1.06) |
| 3 (9.1) | 1,236 | 1.06 (0.98–1.15) | 1.01 (0.93–1.11) | 543 | 1.08 (0.96–1.21) | 0.99 (0.87–1.13) | 321 | 0.97 (0.84–1.13) | 0.97 (0.81–1.16) |
| 4 (11.0) | 1,252 | 1.14 (1.06–1.23) | 1.09 (1.00–1.19) | 548 | 1.16 (1.03–1.31) | 1.12 (0.98–1.27) | 306 | 0.98 (0.84–1.15) | 1.02 (0.86–1.22) |
| 5 (14.8) | 1,369 | 1.34 (1.24–1.45) | 1.26 (1.15–1.38) | 547 | 1.27 (1.12–1.43) | 1.14 (1.00–1.31) | 357 | 1.20 (1.04–1.40) | 1.31 (1.10–1.55) |
| P trend | <0.001 | <0.001 | <0.001 | 0.011 | 0.002 | <0.001 | |||
Abbreviations: CI, confidence interval; HR, hazards ratio; ref, reference.
a
From Cox proportional hazards regression.
b
Adjusted for age (years; continuous), sex (male, female), race (White, Black, Asian, Others), Townsend deprivation index (continuous), assessment centre.
c
Adjusted for age (years; continuous), sex (male, female), race (White, Black, Asian, Others), Townsend deprivation index (continuous), assessment centre, BMI (kg/m2; continuous), smoking status (never, previous, current), alcohol intake status (never, previous, current), physical activity (low, moderate, high), and comorbidities (yes, no).