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[Preprint]. 2023 Jan 20:rs.3.rs-2497474. [Version 1] doi: 10.21203/rs.3.rs-2497474/v1

Figure 3. Standard-of-care BNZ does not fully restore metabolic alterations while vaccine-linked chemotherapy showed greater improvement.

Figure 3.

(A) Treatment timeline. (B) Median parasite burden in each group (log scale). Right ventricle bottom values in naive mice not displayed due to log scale (median of zero). (C) PERMANOVA pseudo-F at 142 days post infection for PCoA distances between naïve mice and the different treatment groups or between infected untreated mice and the different treatment groups. (D) PCoA distances between experimental groups at 142 days post-infection. In particular, BNZ-treated samples were not as distant from infected samples as combo-treated samples at RVB. Red bars, KW with post-hoc Dunn’s test, FDR-corrected p<0.05. RVT, right ventricle top; RVB, right ventricle bottom. N=15 mice per group and per position. (E) Diagram of restoration of metabolic status based on distance analysis from panel D. (F) Parasite burden in individual samples.