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[Preprint]. 2023 Jan 21:rs.3.rs-2468706. [Version 1] doi: 10.21203/rs.3.rs-2468706/v1

Figure 4. Cardiac transcriptional changes in a hamster model of severe SARS-CoV-2.

Figure 4

A. Male 5-to-6-week-old golden Syrian hamsters were IT infected with WA1, or mock challenged with vehicle (PBS), and hearts excised at 4 days post-infection for transcriptomics. B. Log PFU per gram tissue of SARS-CoV-2 in hearts of hamsters (student t-test, p-value < 0.001 ****). C-F. Log fold change (log FC) of transcriptional changes in hearts of infected vs. uninfected hamsters. Representative gene ontology terms selected were C. programmed cell death, D.regulation of ROS, E. defense response to the virus, and F. carbohydrate metabolic processes.