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[Preprint]. 2023 Jan 17:rs.3.rs-2456733. [Version 1] doi: 10.21203/rs.3.rs-2456733/v1

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Vessels of the IDH1-Wildtype GBMs. All vessels here lack pericytes, smooth muscle-cells, and endothelial cells. The basal lamina is either irregularly discontinuous or absent. A. a small vessel with a thickened VW, lipids (L), and tumor cells in VW (*) and lumen (+); B. part of a large vessel with a very thick VW, and tumor cells in VW (*) and lumen (+); C. partial view of a vessel with a thickened and dense VW, lipids (L), and tumor cells in VW (*) and lumen (+); D. partial view of an elongated vessel with thickened VW, and tumor cells invading the VW (*) and lumen (+); the lumen has cellular debris probably from degenerate endothelial cells; E. a close up of D showing a tumor cell in VW and the details of the VW and the proliferative basement membrane; F. a small vessel surrounded by a proliferative basement membrane showing tumor cells (+) and lipid inclusion (L) in the lumen.