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[Preprint]. 2023 Jan 20:rs.3.rs-2457013. [Version 1] doi: 10.21203/rs.3.rs-2457013/v1

Figure 2. Serum viral neutralizing antibody titers in aged vs. young, immunized mice.

Figure 2.

Neutralizing antibody titers measured in sera from mice immunized three times IN with 10 or 20 μg RBD with PBS, NE, or NE/IVT, or IM with RBD with Addavax using lentivirus PSVs expressing SARS-CoV-2 S protein derived from (A) WT, (B) B.1.617.2, (C) B.1.351, (D) B.1.1.529 viral variants. Titers are shown as mean±SEM (n=5/grp) (*p<0.05, **p<0.01 by Mann-Whitney U test shown only for NE/IVT/10 RBD compared to other treatments in the same age group, and for NE/IVT/20 RBD compared only to high dose RBD groups within the young group. Full statistical analysis is shown in Table S1).