Fig. 4. Increased OXTR DNA methylation is associated with increased oxytocin use and total postpartum blood loss only when oxytocin is administered during labor.

Red dots show participants without oxytocin use in labor (n = 38); blue dots denote oxytocin was used in labor (n = 53). Shaded area denotes 95% CI of regression line. A Higher −934 OXTRm is associated with higher intra/postpartum administration of oxytocin among participants receiving oxytocin (blue dots). B Postpartum bleeding volume associated with DNA methylation however, severity increased when oxytocin was used in labor.