Table 2. Lead causal traits identified by Mendelian randomisation Bayesian model averaging (MR-BMA) of lipid-related phenotypes in early age-related macular degeneration (AMD) ranked according to their marginal inclusion probability (MIP).

Rank	Risk factor (trait ID)	MIP	Average effect	Nominal p-value	FDR-adjusted p-value
1	Sphingomyelins (met-c-935)	0.76	0.30	2.40E−04	5.76E−03
2	Phospholipids in very small VLDL (met-c-955)	0.63	−0.31	1.00E−05	7.20E−04
3	Triglycerides in IDL (met-c-872)	0.32	−0.16	2.10E−04	5.76E−03
4	Free cholesterol (met-c-858)	0.20	0.07	2.83E−03	5.09E−02
5	Omega-3 fatty acids (met-c-855)	0.07	0.01	3.70E−02	2.34E−01
6	Free cholesterol in very large HDL (met-c-944)	0.07	0.01	2.74E−02	2.34E−01
7	Total lipids in very small VLDL (met-c-953)	0.06	−0.02	2.08E−02	2.34E−01
8	Cholesterol esters in medium VLDL (met-c-910)	0.05	0.01	3.66E−02	2.34E−01
9	Cholesterol esters in very large HDL (met-c-943)	0.05	0.01	4.87E−02	2.34E−01
10	Ratio of bisallylic groups to double bonds (met-c-844)	0.05	0.01	4.41E−02	2.34E−01