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. Author manuscript; available in PMC: 2023 Jan 27.
Published in final edited form as: Nat Genet. 2022 Feb 3;54(2):134–142. doi: 10.1038/s41588-021-00991-z

Fig. 5 |. Effect of host genetics and prevalent CRC on gut levels of E. faecalis associated with MED13L variation across participants of the FR02 cohort.

Fig. 5 |

Abundances are compared across individuals grouped according to (left panel) MED13L:rs143507801 genotype and (right panel) CRC prevalence according to the Finnish Cancer Registry. The comparison between E. faecalis variation and MED13L:rs143507801 reflects the GWAS results (Supplementary Table 1). The comparison of E. faecalis abundances in individuals with or without a history of CRC at the time of sampling was performed using a Wilcoxon rank test. Sample sizes for compared groups of individuals: rs143507801:A/A (n = 5,825), G/A (n = 130) (note: only 1 of 5,959 individuals in our cohort was G/G); with CRC (n = 14), without a history of CRC at baseline (n = 5,941). For all box plots, the central line, box and whiskers represent the median, IQR and 1.5 times the IQR, respectively. Violin plots represent the distribution density of the data points.