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. 2023 Jan 11;31:295–308. doi: 10.1016/j.omtn.2023.01.003

Figure 1.

Figure 1

Molecular composition of common RNA methylations and m7G modifications in RNAs

(A) Molecular composition of common RNA methylations including m1A, m5C, m6A, and m7G. (B) Secondary structure of tRNA. m7G modification occurs at nucleotide position 46 in the extra loop. (C) Human small ribosomal subunit rRNA m7G can be methylated in the 18S rRNA 3′ major domain at nucleotide position 1639, which locates at a ridge forming a steric block between the P-site and E-site tRNAs at the back of the small subunit head. (D) Secondary structure of pri-let-7e-5p in which m7G modification occurs at nucleotide position 11.