Table 1.
General information about the eight selected proteins for multi-epitope vaccine construction.
| Protein | UniProt ID | Function | Amino acid residue number | Allergenicity | Functional-annotation-based classification | References |
|---|---|---|---|---|---|---|
| EspA | P9WJE1 | ESAT-6-system-1 (ESX-1) secretion-associated protein | 404 | Non-allergen | Secreted/pathogenesis | [88], [89] |
| Mpt63 | P9WIP1 | immunogenic protein | 163 | Non-allergen | Secreted/extracellular space | [90] |
| LprA | P9WK55 | lipoprotein LprA | 252 | Allergen | Secreted/extracellular space | [91] |
| PPE18 | L7N675 | proline-proline-glutamic (PPE) family protein | 403 | Non-allergen | Secreted/pathogenesis | [92] |
| EsxA | P9WNK7 | 6 kDa early secretory antigen | 97 | Non-allergen | Secreted/pathogenesis | [93], [94] |
| EsxB | P9WNK5 | 10 kDa culture filtrate antigen | 102 | Non-allergen | Secreted/pathogenesis | [93] |
| LppX | P9WK65 | phthiocerol dimycocerosate transporter | 239 | Non-allergen | Secreted/pathogenesis | [95] |
| EspC | P9WJD7 | ESAT-6-system-1 (ESX-1) secretion-associated protein | 105 | Allergen | Secreted/pathogenesis | [89] |
| HBHA* | P9WIP9 | heparin binding hemagglutinin | 205 | Non-allergen | Cell surface | [96] |
*
Indicates that the protein is used as adjuvant.