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. 2022 Nov 15;37(1):61–71. doi: 10.1038/s41375-022-01746-3

Fig. 1. Treatment with hypomethylating agents induces upregulation of ATP-binding cassette transporters.

Fig. 1

Expression levels of ATP-binding cassette transporter genes of three KMT2A-rearranged infant ALL cell lines (PER-485, PER-490 and PER-826), incubated with IC10-40 concentrations of (A) azacitidine or (B) decitabine for 72 h were measured by real-time quantitative polymerase chain reaction. The bar plots depict mean log2 fold change of three biological replicates compared to untreated cells with standard error of the mean displayed for each sample. **p < 0.01, ***p < 0.001.