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. 2022 Nov 15;37(1):61–71. doi: 10.1038/s41375-022-01746-3

Fig. 4. Thermal proteome profiling of the ALL-PO KMT2A-rearranged infant acute lymphoblastic leukemia cell line treated with azacitidine or decitabine reveals novel target proteins.

Fig. 4

A Volcano plot of the results obtained from the non-parametric analysis of response curves of thermal proteome profiling data for azacitidine and decitabine with selected significant hits annotated and highlighted in red. B Melt curves showing changes in aggregation temperature for TYMS, NSUN2, NSUN6 and TRDMT1 from azacitidine (magenta) and DMSO (black) treated ALL-PO cells. Melt curves showing changes in aggregation temperature for TYMS, CENPE, KMT2B and ZHX2 from decitabine (cyan) and DMSO (black) treated ALL-PO cells.