TABLE 3.
Humoral immune response to B. burgdorferi antigens among 39 patients with EM
| Assay and antigen | Antibody response by ELISA during phasea
|
||||||||
|---|---|---|---|---|---|---|---|---|---|
| IgM
|
IgG
|
IgM or IgG
|
|||||||
| Acute | Conv | P | Acute | Conv | P | Acute | Conv | P | |
| ELISA | |||||||||
| B. burgdorferi lysate | 14 (36) | 30 (77) | <0.001 | 5 (13) | 23 (59) | <0.001 | 16 (41) | 36 (92) | <0.001 |
| FlaB | 12 (31) | 15 (38) | 0.6 | 10 (26) | 21 (54) | 0.02 | 18 (46) | 28 (72) | 0.04 |
| OspC | 18 (46) | 30 (77) | 0.01 | 15 (38) | 22 (56) | 0.09 | 24 (62) | 34 (87) | 0.02 |
| OspA | 3 (8) | 2 (5) | 1.0 | 3 (8) | 3 (8) | 1.0 | 6 (15) | 5 (13) | 1.0 |
| Any of the above antigens | 23 (59) | 36 (92) | 0.001 | 21 (54) | 32 (82) | 0.01 | 28 (72) | 37 (95) | 0.01 |
| Two-test approachb | 11 (26) | 26 (67) | <0.001 | 2 (5) | 4 (10) | 0.7 | 13 (33) | 29 (74) | <0.001 |
a
Acute- and convalescent (Conv)-phase samples of patients with EM were tested by ELISA for IgM and IgG responses to borrelial antigens. Except for P values, results are presented as number (percent) of samples testing positive.
b
ELISA and Western blotting.