TABLE 5.
Cellular and humoral immune responses to B. burgdorferi antigens according to localized or disseminated infection
| Antigen | Result for patients with indicated infectiona
|
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Proliferation assay
|
IgM or IgG antibody response
|
|||||||||||
| Acute
|
Convalescent
|
Acute
|
Convalescent
|
|||||||||
| Local (n = 13) | Dissem (n = 26) | P | Local (n = 13) | Dissem (n = 26) | P | Local (n = 13) | Dissem (n = 26) | P | Local (n = 13) | Dissem (n = 26) | P | |
| B. burgdorferi lysate | 5 (38) | 12 (46) | 0.7 | 9 (31) | 12 (46) | 0.3 | 4 (31) | 12 (46) | 0.5 | 11 (85) | 25 (96) | 0.3 |
| FlaB | 3 (23) | 0 (0) | 0.03 | 6 (46) | 8 (31) | 0.5 | 6 (46) | 12 (46) | 1.0 | 7 (54) | 21 (81) | 0.1 |
| OspC | 4 (31) | 4 (15) | 0.4 | 6 (46) | 8 (31) | 0.5 | 7 (54) | 17 (65) | 0.5 | 9 (69) | 25 (96) | 0.04 |
| OspA | 3 (23) | 5 (19) | 1.0 | 7 (54) | 10 (38) | 0.5 | 3 (23) | 3 (12) | 0.4 | 0 (0) | 5 (19) | 0.1 |
a
Acute- and convalescent-phase samples from patients with localized infection (Local) or disseminated infection (Dissem) were tested by the indicated assays. Except for P values, results are presented as number (percent) of samples testing positive.