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. 2023 Jan 27;13:1537. doi: 10.1038/s41598-023-28840-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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LINE-1 ORF1p is detected by iMRM-MS in conditioned media, ascites and plasma of HGSOC patients. (A) FT and HGSOC cell lines supernatants and (B) primary HGSOC cells from patients’ ascites were analyzed by iMRM-MS. Light to heavy peptide peak area ratio (PAR) for the single best transition was normalized to amount of protein in each sample. PAR for each sample was normalized to the sample with the highest value and reported as a percentage for each peptide. (C) Light to heavy peptide peak area ratio showing the relative detection and difference between healthy and disease samples of an independent cohort containing 72 cases of HGSOC and 37 healthy controls (N = 109 total patient plasma samples).