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. 2023 Jan 27;13:1537. doi: 10.1038/s41598-023-28840-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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LINE-1 ORF1p expression is an early event in serous ovarian cancer tumorigenesis. (A) LINE-1 ORF1p expression (IHC) in tissue from morphologically benign fallopian tube epithelium (FTE), serous tubal intraepithelial carcinoma (STIC), and invasive high-grade serous ovarian carcinoma (HGSOC). Abundant ORF1p is expressed in STIC lesions and HGSOC while normal FTE is negative. p53 staining identifies the carcinoma cells and Ki-67 the proliferative cells in the STIC and invasive tumor. All micrographs (20X objective) were imaged from one representative case to align the location of the lesions. (B) Cellular distribution of ORF1p in HGSOC. Two representative cases are shown, which exhibit a cytoplasmic and membranous staining pattern (40X objective).