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. 2023 Jan 27;13:1537. doi: 10.1038/s41598-023-28840-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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LINE-1 ORF1p is expressed in incidental STIC lesions. Representative images of hematoxylin and eosin (H&E) staining, p53, and LINE-1 ORF1p expression in fallopian tube epithelium (FTE) and serous tubal intraepithelial carcinoma (STIC) lesions (IHC). Incidental STIC lesions display robust cytoplasmic and pan-cellular ORF1p expression (20X). There is no ORF1p expression in the adjacent benign epithelium. Intense nuclear p53 staining is characteristic of the STIC lesion and is negative in normal tissue. Inset micrographs (40X) highlight the normal ciliated cells in benign FTE and the malignant cells in the STIC lesion.