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. 2022 Aug 17;30(1):111–124. doi: 10.1038/s41418-022-01049-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A The cellular survival curves of HCT116 following SP100-AS1 knockdown using siRNA. B The cell viability of HCT116 cells at a radiation dose of 4 Gy. C The cellular survival curves of SW480 following SP100-AS1 knockdown. D The cell viability of SW480 following 4 Gy of IR. E The expression of γ-H2AX in HCT116 and SW480 cell lines following SP100-AS1 knockdown and the gray intensity histogram of γ-H2AX expression. F Cell apoptosis was evaluated by flow cytometry, and the apoptotic cell percentage was statistically analyzed. n = 3, *P < 0.05, **P < 0.01 compared with the indicated group.