Figure 12.

IPA administration fails to prevent development of fibrosis in Nr1i2^-/-mice. (A) Experimental outline demonstrating the length of DSS administration, followed by a switch to either H₂O or IPA dissolved in H₂O (pH matched) during healing for 25 days (30 days total). (B) Gross colon thickness and (C) representative Masson’s trichrome staining in the colon with associated analysis of microscopic fibrotic area and fibrotic thickness (n = 4–5 per group; scale bar = 100 μm). Data are presented as mean ± standard error of the mean. Student t test.