Figure 16.

Expression levels of NR1I2, PXR target genes, and fibrotic genes in biopsies from patients with active UC or in remission. Data were derived from Gene Expression Omnibus (GEO) dataset GSE59071 (n = 11 controls and n = 74 with UC). Expression of NR1I2, CYP3A4, ABCB1, COL1A1, COL1A2, and COL3A1 in colonic biopsies from non-IBD, UC active sites, UC inactive sites, and UC remission (formerly active sites). One-way analysis of variance with Tukey multiple-comparison test. ∗P < .05, ∗∗P < .01, ∗∗∗P < .005, ns, not significant.