Figure 6.

Loss of the PXR in T cells does not increase the severity of disease or intestinal fibrosis in a chronic model of T-cell driven colitis. (A) Weight loss over the course of 8 weeks after transfer of sorted naive CD4+CD25-CD45Rb^Hi T cells from WT(Nr1i2^+/+) and Nr1i2^-/- mice into C57BL/6 Rag1^-/- mice via intraperitoneal injection. (B) Gross colon thickness and (C) myeloperoxidase (MPO) activity in the colon of Rag1^-/- mice 8 weeks after injection of WT or Nr1i2^-/- CD4+CD25-CD45Rb^Hi T cells. (D) Masson’s trichrome staining of colonic sections with associated quantification of total fibrotic area and fibrotic thickness in Rag1^-/- mice 8 weeks after transfer of WT(Nr1i2^+/+) and Nr1i2^-/- RbHi naive T cells. (n = 8 per group; scale bar = 100 μm). Data are presented as mean ± standard error of the mean. Student t test.