The Patient-Reported Outcomes Measurement Information System (PROMIS-29) is a validated and widely used measure of health-related quality of life in clinical settings, and it has an accompanying value set to calculate utilities. However, it is of limited use in economic evaluations as EuroQol 5-Dimension 5-Level (EQ-5D-5L) is the common measure of interest in economic evaluations.

This study compares a wide range of direct and indirect mapping approaches, including finite mixtures of beta regression (Betamix) and an adjusted limited dependent variable mixture model (ALDVMM) to map PROMIS-29 to EQ-5D-5L.

This study finds mixture models to have relatively better performance and ideal candidate models for mapping.

This study generates a mapping algorithm for transforming PROMIS-29 scores to EQ-5D-5L utilities.