Table 4.

Correlations between TAM subset numbers and clinicopathological characteristics in HER2-positive breast cancer

Clinicopathological features		CD68	CD163			CSF-1R			CD206
		Total	M2-like	M1-like	Ratio	M2-like	M1-like	Ratio	M2-like	M1-like	Ratio
Agea	r	− 0.069	0.080	0.175	0.040	0.081	− 0.272	0.233	− 0.110	0.104	0.060
	P	0.711	0.669	0.400	0.830	0.663	0.139	0.207	0.557	0.576	0.747
Menopausal statusb	P	0.58	0.622	0.415	0.425	0.517	0.039	0.080	0.538	0.667	0.575
Premenopausal	Median	266.67	350.67	1	219	178.5	18	66.14	88.5	161.83	0.65
Perimenopausal	Median	222.33	210.83	1	148.5	115.42	7.33	3.24	51.17	78	0.85
Postmenopausal	Median	102	107.67	1	70.33	63	63.67	0.54	45	51.67	0.35
Tumour gradeb	P	0.283	0.269	0.620	0.426	0.337	0.629	0.729	0.452	0.040	0.028
Grade 1	Median	51.33	76.17	17.17	59.68	46.5	21.17	33.81	39.17	17.17	22.68
Grade 2	Median	183.67	207.67	1	78.17	73.67	18.3	1.01	90.67	20.83	9.52
Grade 3	Median	237.33	300.67	1	243	125.67	3 45	2.55	64.67	170.33	0.36
Tumour sizea	r	− 0.137	− 0.107	0.088	− 0.124	− 0.241	0.196	− 0.303	− 0.204 0.272	0.045	− 0.178
	P	0.462	0.567	0.638	0.507	0.191	0.291	0.098	0.098	0.809	0.339
Lymph node statusc	P	0.453	0.105	0.726	0.175	0.058	0.689	0.206	0.264	0.922	0.626
Positive	Median	102	178.67	1	107.67	63	37.33	1.5	58	52.67	0.41
Negative	Median	251.83	367	1	367	165.42	38.17	2.79	67.17	144	0.62
Lymphovascular invasionc	P	0.518	0.788	0.542	0.829	0.162	0.353	0.196	0.389	0.808	0.914
Positive	Median	86.5	143.17	1	143.17	70.67	49	1.04	49.5	40.5	0.82
Negative	Median	237.33	243	1	118.3	125.67	22.33	2.55	64.67	122	0.57

*P ≤ 0.005

^aSpearman’s rho

^bKruskal–Wallis test

^cMann–Whitney U test

r—correlation coefficient, P—P value, Median—median TAM subset number