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. 2022 Dec 2;197(3):489–501. doi: 10.1007/s10549-022-06785-z

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Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Subgroup analysis: ORR by IRC in the TNBC cohort in the efficacy analysis set. The two-sided 95% CI was calculated using the binomial exact method. The historical ORR with chemotherapy in a similar population is represented by a dashed line on the figure and was estimated to be 25%. Data cutoff: October 9, 2020. BRCA breast cancer susceptibility gene, CI confidence interval, ECOG Eastern Cooperative Oncology Group, IRC independent review committee, ORR objective response rate, TNBC triple-negative breast cancer