Fig.1.
The regulatory machinery of m6A modification. The diagram showed the m6A machinery. The m6A writers mainly contain METTL3, METTL14, WTAP and KIAA1429, which are responsible for methylating at the N6 position of adenosine. The m6A eraser is composed of RNA demethylases such as FTO and ALKBH5 to remove m6A modification from target RNAs. The m6A reader is essential to recognize and decipher m6A modification, which may determine RNA fate to undergo decay, translation, RNA stabilization or RNA processing. The well-documented m6A readers include YTHDF1/2/3, YTHDC1/2/3, IGF2BP1/2/3, and hnRNPA2B1