TABLE 1.
Total | Mutational subgroups | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
All‐wild‐type +pMMR |
KRAS mut +pMMR |
KRAS mut +PIK3CA mut +pMMR |
PIK3CA mut +pMMR |
BRAF mut | Other | p‐value * | ||||
BRAF mut +pMMR |
BRAF mut +dMMR |
Other +pMMR |
Other +dMMR |
|||||||
Number of patients, n (%) | 2344 | 851 (36.3) | 580 (24.7) | 173 (7.4) | 124 (5.3) | 147 (6.3) | 134 (5.7) | 218 (9.3) | 117 (5.0) | |
Age at diagnosis in years, median (range) | 74.0 (55.0–89.0) | 74.0 (55.0–89.0) | 74.0 (56.0–89.0) | 74.0 (60.0–88.0) | 72.0 (58.0–84.0) | 75.0 (56.0–88.0) | 76.0 (62.0–86.0) | 73.0 (56.0–87.0) | 74.0 (57.0–87.0) | <0.001 † |
Sex, n (%) | ||||||||||
Men | 1311 (55.9) | 542 (63.7) | 311 (53.6) | 94 (54.3) | 79 (63.7) | 62 (42.2) | 41 (30.6) | 129 (59.2) | 53 (45.3) | <0.001 |
Women | 1033 (44.1) | 309 (36.3) | 269 (46.4) | 79 (45.7) | 45 (36.3) | 85 (57.8) | 93 (69.4) | 89 (40.8) | 64 (54.7) | |
Tumor location, n (%) | ||||||||||
Colon | 1652 (70.5) | 515 (60.5) | 387 (66.7) | 133 (76.9) | 91 (73.4) | 132 (89.8) | 132 (98.5) | 149 (68.4) | 113 (96.6) | <0.001 |
Rectosigmoid | 239 (10.2) | 116 (13.6) | 74 (12.8) | 13 (7.5) | 11 (8.9) | 3 (2.0) | 1 (0.8) | 20 (9.2) | 1 (0.9) | |
Rectum | 453 (19.3) | 220 (25.9) | 119 (20.5) | 27 (15.6) | 22 (17.7) | 12 (8.2) | 1 (0.8) | 49 (22.5) | 3 (2.6) | |
pTNM stage, n (%) | ||||||||||
I | 459 (19.6) | 194 (22.8) | 119 (20.5) | 29 (16.8) | 18 (14.5) | 10 (6.8) | 19 (14.2) | 52 (23.9) | 18 (15.4) | <0.001 |
II | 877 (37.4) | 305 (35.8) | 185 (31.9) | 74 (42.8) | 53 (42.7) | 47 (32.0) | 65 (48.5) | 75 (34.4) | 73 (62.4) | |
III | 614 (26.2) | 220 (25.9) | 157 (27.1) | 40 (23.1) | 30 (24.2) | 59 (40.1) | 37 (27.6) | 51 (23.4) | 20 (17.1) | |
IV | 330 (14.1) | 102 (12.0) | 105 (18.1) | 27 (15.6) | 18 (14.5) | 27 (18.4) | 10 (7.5) | 35 (16.1) | 6 (5.1) | |
Unknown | 64 (2.7) | 30 (3.5) | 14 (2.4) | 3 (1.7) | 5 (4.0) | 4 (2.7) | 3 (2.2) | 5 (2.3) | – | |
Tumor extension (pT), n (%) | ||||||||||
T1 | 102 (4.4) | 48 (5.6) | 27 (4.7) | 10 (5.8) | 4 (3.2) | 1 (0.7) | 2 (1.5) | 10 (4.6) | – | <0.001 |
T2 | 439 (18.7) | 181 (21.3) | 116 (20.0) | 23 (13.3) | 16 (12.9) | 13 (8.8) | 17 (12.7) | 53 (24.3) | 20 (17.1) | |
T3 | 1511 (64.5) | 522 (61.3) | 373 (64.3) | 117 (67.6) | 89 (71.8) | 101 (68.7) | 94 (70.2) | 129 (59.2) | 86 (73.5) | |
T4 | 221 (9.4) | 67 (7.9) | 46 (7.9) | 20 (11.6) | 10 (8.1) | 27 (18.4) | 19 (14.2) | 21 (9.6) | 11 (9.4) | |
Unknown | 71 (3.0) | 33 (3.9) | 18 (3.1) | 3 (1.7) | 5 (4.0) | 5 (3.4) | 2 (1.5) | 5 (2.3) | ‐ | |
Lymph node involvement (pN), n (%) | ||||||||||
N0 | 1212 (51.7) | 444 (52.2) | 280 (48.3) | 95 (54.9) | 63 (50.8) | 54 (36.7) | 77 (57.5) | 119 (54.6) | 80 (68.4) | <0.001 |
N+ | 853 (36.4) | 297 (34.9) | 234 (40.3) | 59 (34.1) | 40 (32.3) | 81 (55.1) | 44 (32.8) | 75 (34.4) | 23 (19.7) | |
Unknown | 279 (11.9) | 110 (12.9) | 66 (11.4) | 19 (11.0) | 21 (16.9) | 12 (8.2) | 13 (9.7) | 24 (11.0) | 14 (12.0) | |
Differentiation grade, n (%) | ||||||||||
Well | 198 (8.5) | 79 (9.3) | 57 (9.8) | 15 (8.7) | 11 (8.9) | 10 (6.8) | 4 (3.0) | 17 (7.8) | 5 (4.3) | <0.001 |
Moderate | 1528 (65.2) | 597 (70.2) | 381 (65.7) | 122 (70.5) | 86 (69.4) | 69 (46.9) | 66 (49.3) | 150 (68.8) | 57 (48.7) | |
Poor/undifferentiated | 412 (17.6) | 101 (11.9) | 81 (14.0) | 22 (12.7) | 18 (14.5) | 59 (40.1) | 53 (39.6) | 33 (15.1) | 45 (38.5) | |
Unknown | 206 (8.8) | 74 (8.7) | 61 (10.5) | 14 (8.1) | 9 (7.3) | 9 (6.1) | 11 (8.2) | 18 (8.3) | 10 (8.6) | |
Adjuvant therapy, n (%) | ||||||||||
No | 1830 (78.1) | 654 (76.9) | 434 (74.8) | 142 (82.1) | 94 (75.8) | 121 (82.3) | 121 (90.3) | 158 (72.5) | 106 (90.6) | <0.001 |
Yes | 494 (21.1) | 186 (21.9) | 139 (24.0) | 31 (17.9) | 29 (23.4) | 26 (17.7) | 13 (9.7) | 59 (27.1) | 11 (9.4) | |
Unknown | 20 (0.9) | 11 (1.3) | 7 (1.2) | – | 1 (0.8) | – | – | 1 (0.5) | – |
Abbreviations: pMMR, mismatch repair proficient; dMMR, mismatch repair deficient; TNM, tumor‐node‐metastasis; N0, no lymph node metastasis; N+ one or more lymph node metastases.
p‐value for the χ2 test, unless otherwise specified.
p‐value for the Kruskall–Wallis test.