TABLE 3.
Frequencies of the mutational subgroups, stratified on tumor location (colon, rectosigmoid, rectum) and Warburg‐subtype (Warburg‐low, −moderate, −high)
| Total n (%) | Warburg‐low n (%) | Warburg‐moderate n (%) | Warburg‐high n (%) | |
|---|---|---|---|---|
| Colorectal | ||||
| All‐wild‐type+pMMR | 827 (36.5) | 285 (44.1) | 300 (36.6) | 242 (30.2) |
| KRAS mut + pMMR | 554 (24.4) | 128 (19.8) | 226 (27.6) | 200 (24.9) |
| KRAS mut + PIK3CA mut + pMMR | 168 (7.4) | 48 (7.4) | 69 (8.4) | 51 (6.4) |
| PIK3CA mut + pMMR | 118 (5.2) | 43 (6.7) | 36 (4.4) | 39 (4.9) |
| BRAF mut + pMMR | 144 (6.4) | 24 (3.7) | 38 (4.6) | 82 (10.2) |
| BRAF mut + dMMR | 132 (5.8) | 32 (5.0) | 39 (4.8) | 61 (7.6) |
| Other + pMMR | 211 (9.3) | 63 (9.8) | 75 (9.2) | 73 (9.1) |
| Other + dMMR | 114 (5.0) | 23 (3.6) | 37 (4.5) | 54 (6.7) |
| Colon | ||||
| All‐wild‐type + pMMR | 501 (31.2) | 159 (37.1) | 187 (32.2) | 155 (25.9) |
| KRAS mut + pMMR | 374 (23.3) | 81 (18.9) | 154 (26.5) | 139 (23.2) |
| KRAS mut + PIK3CA mut + pMMR | 129 (8.0) | 36 (8.4) | 53 (9.1) | 40 (6.7) |
| PIK3CA mut + pMMR | 88 (5.5) | 34 (7.9) | 29 (5.0) | 25 (4.2) |
| BRAF mut + pMMR | 129 (8.0) | 23 (5.4) | 33 (5.7) | 73 (12.2) |
| BRAF mut + dMMR | 130 (8.1) | 31 (7.2) | 38 (6.5) | 61 (10.2) |
| Other + pMMR | 146 (9.1) | 43 (10.0) | 51 (8.8) | 52 (8.7) |
| Other + dMMR | 111 (6.9) | 22 (5.1) | 36 (6.2) | 53 (8.9) |
| Rectosigmoid | ||||
| All‐wild‐type + pMMR | 112 (50.2) | 51 (66.2) | 35 (45.5) | 26 (37.7) |
| KRAS mut + pMMR | 69 (30.9) | 13 (16.9) | 27 (35.1) | 29 (42.0) |
| KRAS mut + PIK3CA mut + pMMR | 12 (5.4) | 3 (3.9) | 5 (6.5) | 4 (5.8) |
| PIK3CA mut + pMMR | 8 (3.6) | 4 (5.2) | 1 (1.3) | 3 (4.4) |
| BRAF mut + pMMR | 3 (1.4) | 1 (1.3) | – | 2 (2.9) |
| BRAF mut + dMMR | 1 (0.5) | 1 (1.3) | – | – |
| Other + pMMR | 18 (8.1) | 4 (5.2) | 9 (11.7) | 5 (7.3) |
| Other + dMMR | – | – | – | – |
| Rectum | ||||
| All‐wild‐type + pMMR | 214 (49.0) | 75 (53.6) | 78 (48.2) | 61 (45.2) |
| KRAS mut + pMMR | 111 (25.4) | 34 (24.3) | 45 (27.8) | 32 (23.7) |
| KRAS mut + PIK3CA mut + pMMR | 27 (6.2) | 9 (6.4) | 11 (6.8) | 7 (5.2) |
| PIK3CA mut + pMMR | 22 (5.0) | 5 (3.6) | 6 (3.7) | 11 (8.2) |
| BRAF mut + pMMR | 12 (2.8) | – | 5 (3.1) | 7 (5.2) |
| BRAF mut + dMMR | 1 (0.2) | – | 1 (0.6) | – |
| Other + pMMR | 47 (10.8) | 16 (11.4) | 15 (9.3) | 16 (11.9) |
| Other + dMMR | 3 (0.7) | 1 (0.7) | 1 (0.6) | 1 (0.7) |