TABLE 3.
Predictors of risk of recurrence
| Covariates | N | Univariate | Multivariable a | ||
|---|---|---|---|---|---|
| HR (95% CI) | p | HR (95% CI) | p | ||
| Age b | 142 | 1.0 (1.0–1.1) | 0.840 | – | – |
| Female vs. male | 142 | 2.2 (1.0–5.2) | 0.053 | – | – |
| Location (colon vs. rectum) | 142 | 2.5 (1.3–5.0) | 0.008 | 4.2 (1.7–10.6) | 0.002 |
| Differentiation (well or moderate vs. poor) | 124 | 1.8 (0.7–4.2) | 0.174 | – | – |
| T‐stage (T1‐2 vs. T3‐4) | 142 | 3.8 (1.5–12.8) | 0.013 | 2.8 (0.8–13.5) | 0.152 |
| N‐stage (N0 vs. N1‐2) | 142 | 3.5 (1.8–7.0) | <0.001 | 1.4 (0.5–4.0) | 0.547 |
| Intra‐ and/or extra‐mural vascular invasion (no/yes) | 113 | 3.3 (1.4–7.1) | 0.004 | 0.7 (0.2–2.3) | 0.589 |
| Lymphovascular invasion (no/yes) | 129 | 3.7 (1.8–7.8) | <0.001 | 1.6 (0.6–4.6) | 0.326 |
| Perineural invasion (no/yes) | 129 | 3.5 (1.5–7.4) | 0.002 | 2.6 (0.8–7.4) | 0.087 |
| Treatment included surgery (no/yes) | 142 | 2.5 (1.3–5.3) | 0.010 | 0.7 (0.1–4.2) | 0.786 |
| Methylated BCAT1/IKZF1 detected (no/yes) | 142 | 3.1 (1.4–6.5) | 0.004 | 2.6 (0.9–6.5) | 0.049 |
Abbreviation: HR, hazard ratio.
a
The multivariable cox proportional hazard regression modeling only included co‐variates identified to be significant in the univariate analysis and cases with missing data were omitted from multivariable analysis (n = 13). In the resulting sub‐population (n = 108), 24 had recurrence.
b
Analyzed as continuous covariate.