TABLE 2.

Cox regression analysis of OS in SCLC with brain metastases. (Method: Forward LR)

Features	Univariate		Multivariate
	HR (95%CI)	p value	HR (95%CI)	p value
Age
<65	1		1
≥65	1.359 (1.287–1.436)	<0.001	1.164 (1.086–1.247)	<0.001
Gender
Male	1		1
Female	0.951 (0.900–1.004)	0.069	0.916 (0.855–0.982)	0.013
Race
White	1		1
Black	0.977 (0.896–1.067)	0.610	0.933 (0.838–1.038)	0.202
Other	0.874 (0.771–0.992)	0.037	0.706 (0.599–0.831)	<0.001
Marital status
Married	1		1	–
Singled	1.146 (1.084–1.211)	<0.001	1.095 (1.020–1.174)	0.012
Tumor location
Upper lobe	1		–	–
Middle lobe	0.983 (0.857–1.129)	0.812	–	–
Lower lobe	1.110 (1.037–1.187)	0.003	–	–
Overlapping lesion	0.943 (0.753–1.181)	0.609	–	–
Laterality
Left	1		–	–
Right	1.009 (0.953–1.067)	0.767	–	–
Both	1.106 (0.983–1.245)	0.095	–	–
Number of primary sites
1	1		–	–
≥2	1.112 (1.042–1.186)	0.001	–	–
T‐stage
T1	1		1
T2	1.040 (0.938–1.153)	0.454	1.075 (0.958–1.208)	0.219
T3	1.194 (1.075–1.326)	0.001	1.265 (1.123–1.425)	<0.001
T4	1.146 (1.041–1.263)	0.006	1.192 (1.066–1.332)	0.002
N‐stage
N0	1		1
N1	0.971 (0.860–1.096)	0.632	1.094 (0.940–1.271)	0.245
N2	1.185 (1.091–1.287)	<0.001	1.347 (1.214–1.494)	<0.001
N3	1.244 (1.134–1.366)	<0.001	1.452 (1.292–1.632)	<0.001
Liver metastases
No	1		1
Yes	1.488 (1.403–1.578)	<0.001	1.415 (1.306–1.533)	<0.001
Lung metastases
No	1		–	–
Yes	1.256 (1.171–1.347)	<0.001	–	–
Bone metastases
No	1		1
Yes	1.233 (1.160–1.309)	<0.001	1.126 (1.039–1.221)	0.004
Chemotherapy
No	1		1
Yes	0.292 (0.274–0.311)	<0.001	0.278 (0.256–0.303)	<0.001
Radiotherapy
No	1		1
Yes	0.538 (0.506–0.571)	<0.001	0.733 (0.676–0.795)	<0.001
Surgery
No	1		–	–
Yes	0.563 (0.414–0.766)	<0.001	–	–