Table 1.

Characteristics of samples in the case-control study cohorts.

Variables		TCGA-dbGaP cohort		BioMe cohort
		Cases (6371)	Controls (6647)	Cases (1571)	Controls (6200)
Gender	Male	3099 (48.64%)	4034 (60.69%)	690 (43.92%)	3150 (50.81%)
	Female	3230 (50.70%)	2610 (39.27%)	881 (56.08%)	3050 (49.19%)
	Missing	42 (0.66%)	3 (0.05%)	0	0
Age	Mean (yrs)	60.20	57.54	–	–
	Unknown	86 (1.35%)	4509 (67.84%)
Smoking	Never	448 (7.03%)	322 (4.84%)	1391 (88.54%)	5418 (87.39%)
	Yes	1491 (23.40%)	746 (11.22%)	174 (11.08%)	744 (12.00%)
	Unknown	4432 (69.57%)	5579 (83.93%)	6 (0.38%)	38 (0.61%)