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. 2023 Jan 27;7:14. doi: 10.1038/s41698-023-00352-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a An example H&E tissue; b H&E tissue segmentation result; c IHC tissue (aligned to a) after non-rigid registration; d IHC segmentation results, after non-rigid registration. e Selected representative patches from b including (1) H&E patch, (2) H&E segmentation, (3) H&E segmentation (segm. in short) fused with original patch, (4) IHC patch after registration, (5) IHC patch after registration fused with H&E patch, and (6) H&E, IHC segmentation fused patch; f IMPRESS feature graphical demonstration. In f, each IHC marker produces 11 features (CD8 was shown as an example), H&E region produces 3 features, totally 36 IMPRESS features. Figure best viewed in color.