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. 2023 Jan 27;6:106. doi: 10.1038/s42003-023-04442-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a A schematic depiction of the focal zone-fear conditioning. b The focal fear-conditioning timeline. c The fear-conditioning and pre/post-test schedules. d A representative tracking of the center point of a mouse both before (Pre) and after (Post) the shock session. e Time in the shock zone before and after the shock session (n = 16; paired two-tailed t-test,). f The number of entries into the shock zone before and after the shock session (n = 16; Wilcoxon Signed Rank Test). g Freezing percentage before and after the shock session (n = 16; Wilcoxon Signed Rank Test). h The percentage of distance moved in the shock zone before and after the shock session (n = 16; paired two-tailed t-test). ***p < 0.001. All error bars represent s.e.m. Further information on statistical analyses is given in the supplementary data 1.