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. 2022 Aug 6;30(1):69–81. doi: 10.1038/s41418-022-01046-4

Fig. 4. Deferiprone (DFP) treatment reduced pathologically high intraocular pressure (ph-IOP) induced iron accumulation in vitro and in vivo.

Fig. 4

a High-Performance Liquid Chromatography showed a detectable DFP absorption peak (at 5.1 min) both in the serum and the retina after mice were administered orally with 200 mg/kg DFP for 60 min. b Retinal iron content of sham operation (SO) mice and ph-IOP injured mice, with or without DFP treatment (n = 5 in each group). c Cytoplasmic ferrous iron stained using FerroOrange in the control and oxygen-glucose deprivation/ reoxygenation (OGD/R) groups, with or without DFP treatment. Data are shown as the mean ± SD; **p < 0.01 (compared with the SO group using one-way analysis of variance); #p < 0.05, ##p < 0.01 (compared with ph-IOP 1 h group using one-way analysis of variance). Bar = 100 μm.