TABLE 1.

Distribution of case numbers of important variants of 724 cancer‐related genes in (A) 1491 participants and (B) three subgroups

(A)
		Coding area			Non‐coding area
		ClinVar	None		ClinVar	None
		P/LP	CADD ≧30	LoF	P/LP	CADD ≧30	Splicing
WGS	724 cancer‐related genes	74	573	177	31	300	139

(B)
Subgroup (cases) Targeted panel	FC (131 cases)						1MC (394 cases)						nMC (966 cases)
Variant types	Coding area			Non‐coding area			Coding area			Non‐coding area			Coding area			Non‐coding area
	ClinVar	None		ClinVar	None		ClinVar	None		ClinVar	None		ClinVar	None		ClinVar	None
	P/LP	CADD ≧30	LoF	P/LP	CADD ≧30	Splicing	P/LP	CADD ≧30	LoF	P/LP	CADD ≧30	Splicing	P/LP	CADD ≧30	LoF	P/LP	CADD ≧30	Splicing
724 cancer‐related genes	9	67	17	2	30	9	19	154	46	9	81	41	46	352	114	20	189	89

Note: The important variants were selected based on Figure 1C approach.

Abbreviation: P/LP, pathogenic/likely pathogenic.