Skip to main content
. 2022 Jul 19;12(2):1984–1996. doi: 10.1002/cam4.5043

TABLE 1.

Summary information on MDD‐associated SNPs used as genetic instrumental variables (IVs) for the two‐sample Mendelian randomization (MR) analyses

SNP Chr Position Effect allele Other allele EAF β SE P‐value R 2 F‐statistic
rs301799 1 8,489,302 T C 0.5694 −0.0250 0.0035 1.36 × 10−12 1.08 × 10−3 247.571
rs1002656 1 37,192,741 T C 0.7033 −0.0266 0.0038 3.74 × 10−12 1.04 × 10−3 238.531
rs1466887 1 37,709,328 T C 0.5511 −0.0199 0.0036 4.12 × 10−8 6.91 × 10−4 158.258
rs11579246 1 50,559,162 A G 0.9067 0.0381 0.0061 5.71 × 10−10 8.66 × 10−4 198.380
rs1890946 1 52,342,427 T C 0.4671 −0.0235 0.0035 2.68 × 10−11 9.69 × 10−4 222.078
rs10789214 1 67,146,817 T C 0.5661 0.0193 0.0035 4.44 × 10−8 6.45 × 10−4 147.799
rs2568958 1 72,765,116 A G 0.6156 0.0373 0.0036 8.47 × 10−25 2.32 × 10−3 532.085
rs10890020 1 73,668,836 A G 0.5156 −0.0277 0.0035 4.03 × 10−12 1.35 × 10−3 309.627
rs113188507 1 80,809,636 A G 0.2838 0.0221 0.0039 1.87 × 10−8 7.00 × 10−4 160.366
rs10913112 1 175,913,828 T C 0.3767 −0.0264 0.0036 3.40 × 10−13 1.15 × 10−3 264.386
rs72710803 1 177,428,018 A C 0.9121 −0.0410 0.0062 5.29 × 10−11 9.50 × 10−4 217.726
rs169235 1 181,740,924 A G 0.753 −0.0229 0.0041 2.98 × 10−8 6.88 × 10−4 157.559
rs17641524 1 197,704,717 T C 0.2091 −0.0320 0.0043 1.52 × 10−13 1.19 × 10−3 273.601
rs12052908 2 22,503,044 A T 0.5325 −0.0220 0.0035 4.44 × 10−10 8.49 × 10−4 194.646
rs1568452 2 58,012,833 T C 0.3851 0.0248 0.0036 8.12 × 10−12 1.03 × 10−3 235.290
rs7585722 2 86,819,128 T C 0.8458 −0.0269 0.0048 2.68 × 10−8 6.65 × 10−4 152.452
rs1226412 2 157,111,313 T C 0.7917 0.0256 0.0043 3.46 × 10−9 7.62 × 10−4 174.590
rs62188629 2 208,044,470 A G 0.3136 0.0236 0.0038 7.13 × 10−10 8.45 × 10−4 193.676
rs4346585 3 44,736,493 T C 0.696 −0.0236 0.0038 7.13 × 10−10 8.31 × 10−4 190.373
rs13084037 3 49,214,066 A G 0.774 −0.0245 0.0042 7.08 × 10−9 7.40 × 10−4 169.616
rs7624336 3 53,244,151 T G 0.2087 0.0238 0.0043 3.96 × 10−8 6.60 × 10−4 151.110
rs141954845 3 61,192,911 A G 0.388 0.0229 0.0037 8.15 × 10−10 8.78 × 10−4 201.167
rs6783233 3 117,509,984 T C 0.2833 0.0218 0.0039 2.90 × 10−8 6.80 × 10−4 155.875
rs1095626 3 157,977,962 T C 0.5799 −0.0264 0.0035 7.13 × 10−14 1.20 × 10−3 274.319
rs7685686 4 3,207,142 A G 0.5753 0.0202 0.0036 2.57 × 10−8 7.03 × 10−4 161.050
rs34937911 4 42,110,353 T C 0.8838 0.0304 0.0055 4.13 × 10−8 6.69 × 10−4 153.315
rs45510091 4 123,186,393 A G 0.9472 0.0448 0.0080 1.83 × 10−8 7.08 × 10−4 162.149
rs35553410 4 131,237,381 T C 0.7462 −0.0244 0.0040 1.42 × 10−9 7.95 × 10−4 182.146
rs7659414 4 177,350,956 A C 0.5782 −0.0201 0.0035 1.20 × 10−8 6.95 × 10−4 159.169
rs60157091 5 61,509,655 T C 0.515 0.0200 0.0035 1.42 × 10−8 7.04 × 10−4 161.395
rs3099439 5 87,545,318 T C 0.5288 −0.0276 0.0035 5.05 × 10−15 1.34 × 10−3 306.673
rs10061069 5 93,071,630 C G 0.2212 −0.0275 0.0042 8.15 × 10−11 9.18 × 10−4 210.467
rs30266 5 103,972,357 A G 0.3296 0.0308 0.0037 1.45 × 10−16 1.48 × 10−3 338.688
rs11135349 5 164,523,472 A C 0.4713 −0.0295 0.0035 6.04 × 10−17 1.53 × 10−3 350.376
rs200949 6 27,835,435 A G 0.8744 0.0480 0.0053 2.53 × 10−19 1.78 × 10−3 408.881
rs9363467 6 66,565,703 T C 0.6035 0.0237 0.0036 6.44 × 10−11 9.48 × 10−4 217.135
rs7758630 6 101,387,304 A T 0.4051 −0.0225 0.0036 5.56 × 10−10 8.60 × 10−4 197.094
rs1933802 6 105,365,891 C G 0.4536 −0.0223 0.0035 2.57 × 10−10 8.69 × 10−4 199.111
rs2876520 6 142,996,618 C G 0.5271 −0.0230 0.0036 2.29 × 10−10 9.30 × 10−4 213.024
rs725616 6 147,950,422 T C 0.3644 0.0204 0.0036 1.87 × 10−8 6.80 × 10−4 155.705
rs2029865 6 165,121,844 A T 0.4534 −0.0201 0.0035 1.20 × 10−8 7.06 × 10−4 161.743
rs3823624 7 2,110,346 T C 0.8067 0.0272 0.0045 1.99 × 10−9 8.13 × 10−4 186.370
rs2043539 7 12,253,880 A G 0.4177 0.0273 0.0035 9.89 × 10−15 1.28 × 10−3 292.880
rs2247523 7 82,454,404 C G 0.5319 −0.0207 0.0035 4.38 × 10−9 7.52 × 10−4 172.344
rs16887442 7 82,936,909 T C 0.4347 0.0203 0.0035 8.62 × 10−9 7.14 × 10−4 163.585
rs58104186 7 109,099,919 A G 0.4689 0.0237 0.0035 1.82 × 10−11 9.86 × 10−4 225.980
rs7807677 7 117,502,574 T C 0.5505 0.0237 0.0035 1.82 × 10−11 9.80 × 10−4 224.543
rs7837935 8 65,562,019 T G 0.1522 −0.0292 0.0049 3.34 × 10−9 7.76 × 10−4 177.732
rs67436663 8 71,347,626 C G 0.2402 −0.0259 0.0042 9.37 × 10−10 8.63 × 10−4 197.776
rs1354115 9 2,983,774 A C 0.6243 0.0210 0.0036 7.08 × 10−9 7.29 × 10−4 167.093
rs1982277 9 11,513,019 T C 0.7594 0.0279 0.0041 1.45 × 10−11 1.00 × 10−3 229.770
rs263645 9 17,016,503 A T 0.5438 0.0221 0.0035 3.70 × 10−10 8.54 × 10−4 195.740
rs3793577 9 23,737,627 A G 0.4665 −0.0229 0.0035 8.41 × 10−11 9.20 × 10−4 210.846
rs59283172 9 25,232,978 A G 0.1069 −0.0329 0.0057 1.02 × 10−8 7.29 × 10−4 166.938
rs34653192 9 31,124,452 C G 0.3196 −0.0229 0.0038 2.23 × 10−9 8.04 × 10−4 184.220
rs7030813 9 36,999,369 T C 0.3736 0.0253 0.0036 3.07 × 10−12 1.06 × 10−3 242.005
rs10817969 9 119,731,045 T G 0.7173 0.0261 0.0039 3.11 × 10−11 9.74 × 10−4 223.163
rs913930 9 120,484,009 A G 0.6433 −0.0208 0.0037 2.42 × 10−8 7.00 × 10−4 160.371
rs2670139 9 126,634,255 T C 0.7609 −0.0266 0.0041 1.21 × 10−10 9.07 × 10−4 207.959
rs997934 10 1,795,194 T C 0.3795 0.0198 0.0036 4.81 × 10−8 6.51 × 10−4 149.128
rs1021363 10 106,610,839 A G 0.3547 0.0303 0.0037 4.41 × 10−16 1.48 × 10−3 339.536
rs1448938 11 30,892,824 A G 0.4171 0.0214 0.0035 1.30 × 10−9 7.85 × 10−4 179.868
rs2509805 11 57,650,796 T C 0.3209 0.0220 0.0038 9.17 × 10−9 7.44 × 10−4 170.387
rs198457 11 61,471,678 T C 0.1925 −0.0292 0.0046 2.99 × 10−10 9.34 × 10−4 214.116
rs58621819 11 65,314,830 A T 0.7903 −0.0245 0.0043 1.57 × 10−8 7.01 × 10−4 160.696
rs7117514 11 70,544,937 A G 0.5417 −0.0204 0.0035 7.29 × 10−9 7.28 × 10−4 166.899
rs7932640 11 88,744,425 T C 0.4417 0.0281 0.0035 1.62 × 10−15 1.37 × 10−3 314.610
rs61902811 11 113,370,758 A G 0.3682 −0.0257 0.0036 1.40 × 10−12 1.08 × 10−3 248.232
rs2187490 11 118,713,180 T G 0.9106 −0.0338 0.0061 3.82 × 10−8 6.56 × 10−4 150.236
rs57344483 11 127,022,560 A G 0.9259 −0.0380 0.0068 1.82 × 10−8 6.99 × 10−4 160.041
rs78337797 12 23,987,925 T G 0.8781 0.0306 0.0055 3.37 × 10−8 7.07 × 10−4 161.910
rs56314503 12 84,465,022 T G 0.7487 −0.0254 0.0040 2.95 × 10−10 8.56 × 10−4 196.096
rs10774600 12 110,741,356 T C 0.1656 −0.0267 0.0048 3.39 × 10−8 6.95 × 10−4 159.125
rs3213572 12 121,205,078 A G 0.4745 0.0217 0.0035 7.61 × 10−10 8.28 × 10−4 189.682
rs1409379 13 31,907,741 T C 0.7641 0.0249 0.0041 1.67 × 10−9 7.88 × 10−4 180.538
rs1343605 13 53,647,048 A C 0.384 0.0313 0.0036 6.23 × 10−18 1.63 × 10−3 374.453
rs9592461 13 66,941,792 A G 0.4874 0.0216 0.0035 9.10 × 10−10 8.22 × 10−4 188.308
rs9545360 13 80,826,373 A C 0.1807 −0.0271 0.0046 5.02 × 10−9 7.67 × 10−4 175.642
rs4772087 13 99,115,041 T C 0.3732 0.0227 0.0036 3.91 × 10−10 8.50 × 10−4 194.725
rs61990288 14 42,074,726 A G 0.5083 −0.0260 0.0035 1.68 × 10−13 1.19 × 10−3 272.966
rs1956373 14 60,141,822 T G 0.7436 −0.0226 0.0040 2.06 × 10−8 6.87 × 10−4 157.309
rs1152578 14 64,697,037 T C 0.4357 −0.0218 0.0035 6.36 × 10−10 8.24 × 10−4 188.759
rs1045430 14 75,130,235 T G 0.4792 −0.0253 0.0035 7.31 × 10−13 1.13 × 10−3 258.085
rs10149470 14 104,017,953 A G 0.4869 −0.0267 0.0035 3.72 × 10−14 1.26 × 10−3 287.749
rs8037355 15 37,643,831 T C 0.5556 −0.0233 0.0035 3.94 × 10−11 9.45 × 10−4 216.551
rs34488670 15 47,684,936 T C 0.7887 −0.0252 0.0043 6.03 × 10−9 7.46 × 10−4 170.962
rs7193263 16 6,315,880 A G 0.6679 −0.0239 0.0038 4.33 × 10−10 8.93 × 10−4 204.683
rs7198928 16 7,666,402 T C 0.6159 0.0239 0.0036 4.45 × 10−11 9.53 × 10−4 218.305
rs7200826 16 13,066,833 T C 0.2551 0.0280 0.0040 3.74 × 10−12 1.05 × 10−3 240.685
rs56887639 16 13,755,530 A G 0.7264 −0.0278 0.0039 1.51 × 10−12 1.08 × 10−3 248.148
rs12923444 16 21,639,710 A C 0.5625 −0.0214 0.0035 1.30 × 10−9 7.95 × 10−4 182.063
rs75581564 17 27,363,750 A G 0.1165 0.0301 0.0054 3.17 × 10−8 6.58 × 10−4 150.640
rs12967855 18 35,138,245 A G 0.3295 0.0265 0.0037 1.18 × 10−12 1.09 × 10−3 250.655
rs7227069 18 50,731,802 A G 0.4326 0.0238 0.0035 1.50 × 10−11 9.80 × 10−4 224.619
rs62091461 18 52,488,672 T C 0.2274 −0.0254 0.0042 1.95 × 10−9 7.99 × 10−4 183.108
rs12966052 18 52,751,639 C G 0.1805 −0.0314 0.0046 1.25 × 10−11 1.03 × 10−3 235.617
rs12967143 18 53,099,012 C G 0.6984 −0.0312 0.0038 3.70 × 10−16 1.44 × 10−3 331.297
rs7241572 18 77,580,712 A G 0.201 0.0280 0.0044 2.70 × 10−10 8.88 × 10−4 203.406
rs33431 19 30,939,989 T C 0.6144 0.0198 0.0036 4.81 × 10−8 6.55 × 10−4 150.036
rs143186028 20 39,997,404 T G 0.1778 0.0277 0.0046 2.29 × 10−9 7.91 × 10−4 181.201
rs12624433 20 44,680,853 A G 0.2584 0.0233 0.0040 7.44 × 10−9 7.34 × 10−4 168.058
rs5995992 22 41,487,218 T C 0.7155 −0.0266 0.0039 1.30 × 10−11 1.02 × 10−3 232.689

Abbreviations: EAF, effect allele frequency; SE, standard error; SNP, single‐nucleotide polymorphism.